Telomere regulation and aging

Cell growth and proliferation are essential for tissue homeostasis. However, DNA replication during these processes causes a progressive shortening of chromosome termini, known as telomeres, due to the end-replication problem. This intrinsic genomic instability contributes to both cellular and organismal aging, and manifestes as telomere biology disorders (TBDs).
Using tissue-cultured cells and genetically engineered mouse models, we aim to elucidate the molecular mechanisms by which dysfunctional telomeres cause cellular responses and tissue malfunction. In addition, we are investigating the possibility of targeting cellular signaling pathways as a strategy for managing human aging processes and developing TBD therapeutics.